The neocortex, seat of higher cognitive functions in humans, is populated by specialized neurons that are generated from neural stem cells during development. Precise temporal and spatial control of neural stem cell biology and behavior by a concert of regulatory factors is essential for the correct formation and proper function of the neocortex. Our lab is interested in understanding how do placental factors regulate the proliferation and differentiation of neural stem cells during neocortical development. We take a multidisciplinary approach, combining bioinformatic tools with cutting-edge molecular techniques and advanced microscopic imaging, to address our research question. By utilizing genetically modified mouse models and stem cell-derived 3D organoids, we aim to characterize the cellular and molecular mechanisms underlying human brain development, evolution and neurodevelopmental and neuropsychiatric disorders, such as Autism Spectrum Disorder (ASD) and schizophrenia.
